1860 - Reported as a new presbytery at General Assembly by McAdow Synod

1885 - Became part of Missouri Synod (McAdow Synod dissolved)

1907 - Attached to McGee Presbytery

1859
December 2, 1859 - Kirksville, Missouri
Modertor: Rev. Samuel B. F. Caldwell
Clerk: Rev. S. C. Davidson
photocopy of manuscript minutes in archives

1869
September 23-25 & 27, 1869 - Kirksville, Missouri
Moderator: Rev. David Walker
Clerk: Rev. Jesse Wilson
1 printed minute in archives

1870
February 23-26, 1870 - Kirksville, Missouri
Moderator: Rev. John Neff
Stated Clerk (resigned): Rev. R. H. Wills
Stated Clerk (elected): Rev. S. C. Davidson
1 printed minute in archives

1870
August 24, 1870 - Liberty Cumberland Presbyterian Church - Macon County, Missouri
No printed minutes in archives

1876
February 23-26, 1876 - New Harmony Cumberland Presbyterian Church - Macon County, Missouri
Moderator: Rev. David Walker
Permanent Clerk: Rev. Jesse Wilson
1 printed minute in archives

1876
September 20-22, 1876 - Bethel Cumberland Presbyterian Church - Scotland County, Missouri
Moderator: Rev. M. C. Patton
Stated Clerk: Rev. S. C. Davidson
Permanent Clerk (resigned): Rev. Jesse Wilson
Clerk, pro tem: Rev. J. Neff
2 printed minutes in archives

1877
February 7-10, 1877 - Shiloh Cumberland Presbyterian Church - Macon County, Missouri
Moderator: Rev. M. C. Patton
Clerk: Rev. W. H. Johnston
2 printed minutes in archives

1877
September 19, 1877 - New Providence Cumberland Presbyterian Church - Shelby County, Missouri
No printed minutes in archives

1879
April 3-5, 1879 - Unity Cumberland Presbyterian Church - Scotland County, Missouri
Moderator: Rev. J. B. Lowrance
Clerk: Rev. W. H. Johnston
2 printed minutes in archives

1879
September 18, 1879 - La Plata Cumberland Presbyterian Church - La Plata, Macon County, Missouri
No printed minutes in archives