1837 - 1st appearance on the General Assembly roll
Part of Franklin Synod.

1840 - Attached to newly formed Middle Tennessee Synod
Resolved, that the Franklin Synod be and it is hereby dissolved, and that the Knoxville and Hiwassee Presbyteries be attached to the Middle Tennessee Synod, and the Jackson Presbytery be attached to the Columbia Synod.
[Source: Minutes of the General Assembly of the Cumberland Presbyterian Church, 1840.]

1843 - Became part of newly formed East Tennessee Synod

That the General Assembly of the Cumberland Presbyterian Church be and is hereby respectfully petitioned to divide Middle Tennessee Synod by striking off the Hiwassee, Knoxville and Ocoee Presbyteries, and form a new one to be known by the name of the East Tennessee Synod, and include said three Presbyteries. That the first meeting of said Synod be held at Fork Creek Church, Monroe County, Tennessee, on Friday before the third Sabbath in October, 1843, and that Rev. John Tate be appointed the first Moderator and Rev. James W. Ramsay his alternate.
[Source: Minutes of the General Assembly of the Cumberland Presbyterian Church, 1843.]

1888 - Became part of Tennessee Synod (consolidation of Columbia, East Tennessee, Middle Tennessee, and West Tennessee Synods)

The Synods in Tennessee also memorialize this General Assembly to allow them to be consolidated into one, called the Synod of Tennessee. Your committee [Committee on Overtures] recommend that the petition be granted, and that the consolidated Synod of Tennessee meet in the Cumberland Presbyterian Church, McMinnville, on Tuesday, October 23, 1888, at 7:30 o'clock P.M. This report was adopted.
[Source: Minutes of the General Assembly of the Cumberland Presbyterian Church, 1888, pages 29-30]

1890 - Name changed to Knoxville Presbytery

Report of the Committee on Overtures was adopted. Memorials have come before this committee as follows: (3) From Hiwassee Presbytery, asking that its name be changed to Knoxville.
[Source: Minutes of Tennessee Synod of the Cumberland Presbyterian Church, October 23, 1890, page 10]